ANTICANCER POTENTIAL
Cancer and Guava
The Cancer, is the second most common cause of death, is one the leading global health issues we face today (World Health Organization 2018).
By the year 2035, the World Health Organization projects that there will be 24 million new cancer cases and 14.5 million cancer-related deaths per year (World Health Organization 2003).
Approximately, 30 to 40% of cancers are preventable by appropriate dietary and nutritional measures and maintenance of a healthy body weight (Glade, 1999).
Research has postulated that consumption of a diet high in fruits (more than 400 g/day) could prevent at least 20% of all cancers (Gullett et al. 2010)
Currently, there are numerous individual reports on the anticancer effects of Guava fruit, making it a promising potential resource for the development of novel agents for cancer prevention due to its cellular and molecular mechanisms of action.
Flavonoids are a common component of guava fruit that have demonstrated anticancer activities.
Guava fruit constituents exert anticancer effects in different stages of cancer initiation, promotion, progression, and metastasis.
Antioxidant and anti-inflammatory compounds prevent the initiation stage of cancer and promote DNA repair.
The literature demonstrates the potential of using guava fruit for the prevention and intervention of various cancer subtypes including breast, gastrointestinal, genitourinary, neurological, pulmonary, hematological, renal, and skin cancer.
Bibliographic reference
- Bjelakovic, G., D. Nikolova, L. L. Gluud, R. G. Simonetti, and C. Gluud. 2008. Antioxidant supplements for preventing gastrointestinal cancers. Cochrane Database of Systematic Reviews (2):CD007176. doi: 10.1002/14651858.CD007176.
- dos Santos, R. C., A. S. Ombredane, J. Souza, A. G. Vasconcelos, A. Plácido, A. Amorim, E. A. Barbosa, F. Lima, C. D. Ropke, M. Alves, et al. 2018. Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF-7 via an apoptotic-like pathway. Food Research International (Ottawa, ON) 105:184–96. doi: 10.1016/j.foodres.2017.10.045.
- Jamieson, S., Wallace, C. E., Das, N., Bhattacharyya, P., & Bishayee, A. (2022). Guava (Psidium guajava L.): a glorious plant with cancer preventive and therapeutic potential. Critical Reviews in Food Science and Nutrition, 63(2), 192-223.
- Ashraf, A., R. A. Sarfraz, M. A. Rashid, A. Mahmood, M. Shahid, and N. Noor. 2016. Chemical composition, antioxidant, antitumor, anticancer and cytotoxic effects of Psidium guajava leaf extracts. Pharmaceutical Biology 54 (10):1971–81
Cancer and Mango
There are numerous individual experimental reports on anticancer effects of various constituents from the mango tree, an up-to-date, comprehensive and critical review of available research data on cancer prevention and intervention by various bioactive components.
Countries use mango constituents to treat various ailments and diseases, such as anemia, malaria, diarrhea, gastric disorders, hepatic disorders, cough, jaundice, anemia, hemorrhage, ulcers and diabetes
Cancer types that are impacted by Mango fruit phytochemicals include gastric cancer, colon cancer, liver cancer, pancreatic cancer, lung cancer, breast cancer, ovarian cancer, uterine cancer, prostate cancer, neural, skin, and hematological cancers.
The limited toxicity studies conclude that Mango fruit and its major component mangiferin are safe. M. indica, with its limited toxicity, may present as an alternative to traditional cancer chemotherapy which are associated with undesirable adverse effects.
Mangiferin is unique to Mango fruit, it is the primary phytochemical examined in anticancer research.
Mango fruit -derived phytoconstituents have the potential to be developed as a valuable pharmaceutical for cancer prevention as well as multitargeted agent for pharmacotherapy of cancer.
Bibliographic reference
- Mirza, B., Croley, C. R., Ahmad, M., Pumarol, J., Das, N., Sethi, G., & Bishayee, A. (2021). Mango (Mangifera indica L.): a magnificent plant with cancer preventive and anticancer therapeutic potential. Critical Reviews in Food Science and Nutrition, 61(13), 2125-2151.
- Abdullah, A.-S. H., A. S. Mohammed, R. Abdullah, M. E. S. Mirghani, and M. Al-Qubaisi. 2014. Cytotoxic effects of Mangiferaindica L. kernel extract on human breast cancer (MCF-7 and MDA-MB-231 cell lines) and bioactive constituents in the crude extract. BMC Complementary and Alternative Medicine 14:199. doi: 10.1186/1472-6882-14-199.
- Banerjee, N., H. Kim, K. Krenek, S. T. Talcott, and S. U. Mertens-Talcott. 2015. Mango polyphenolics suppressed tumor growth in breast cancer xenografts in mice: Role of the PI3K/AKT pathway and associated microRNAs. Nutrition Research (New York, N.Y.) 35 (8):744–51. 8:doi: 10.1016/j.nutres.2015.06.002.
Cancer and Lulo
Bibliographic reference
- Betoret, N., Hinestroza, L. I., Seguí, L., & Barrera, C. (2019). Probiotics and other bioactive compounds with proven effect against obesity and hypertension: food design opportunities from Lulo Fruit (Solanum quitoense)*. Nutraceuticals-Past, Present and Future, 59.
